D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation for Major Depressive Disorder (Cole, Sohn et al., 2022)

Evan Bartholomeusz

Published on: 09/06/2026

This was a randomized, double-blind, placebo-controlled clinical trial evaluating whether D-cycloserine improves the antidepressant effects of intermittent theta burst stimulation when administered immediately before each TMS session.

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The THREE-D Trial - iTBS Non-Inferior to Standard rTMS for Depression (Blumberger et al. 2018)

Evan Bartholomeusz

Published on: 08/06/2026

The THREE-D trial is the largest randomized controlled trial comparing intermittent theta burst stimulation to standard high-frequency rTMS for major depressive disorder.

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